1979: "Exo-Disco" (as Huey Lewis and the American Express)
1980: "Some of My Lies Are True (Sooner or Later)"
"Now Here's You"
1982: "Do You Believe In Love" (#7, #18 Australia)
"Hope You Love Me Like You Say You Do" (#36)
"Workin' For a Livin'" (#41)
1983: "Heart and Soul" (#8, #25 Australia, #61 U.K.)
1984: "I Want a New Drug" (#6, #27 Australia)
"The Heart of Rock and Roll" (#6, #58 Australia, #78 U.K.)
"If This Is It" (#6, #5 Adult Contemporary, #20 Australia, #39 U.K.)
"Walking On a Thin Line" (#18, #70 Australia)
1985: "The Power of Love" (#1, #6 AC, #1 Australia, #11 U.K.)
"Back In Time" (#3 Mainstream Rock)
1986: "The Power of Love" (re-issue) --#9 U.K.
"The Heart of Rock and Roll" (re-issue) --#49 U.K.
"Stuck With You" (#1, #1 AC, 2 Australia, #12 U.K.)
"Hip To Be Square" (#3, #20 AC, #17 Australia, #41 U.K.)
"Some of My Lies Are True (Sooner or Later) --re-issue
1987: "Jacob's Ladder" (#1, #17 AC, #48 Australia)
"I Know What I Like" (#9, #30 AC)
"Simple As That"
"Doing It All For My Baby" (#6, #2 AC, #93 U.K.)
1988: "Perfect World" (#3, #1 AC, #22 Australia, #48 U.K.)
"Small World, Part 1" (#25, #19 AC)
1989: "Give Me the Keys (And I'll Drive You Crazy) --#47, #42 AC
"World To Me" (#84 U.K.)
"Walking With the Kid" (#98 U.K.)
1991: "Couple Days Off" (#11, #3 Mainstream Rock, #40 Australia)
"It Hit Me Like a Hammer" (#21, #10 AC)
"He Don't Know" (#40 AC)
1993: "It's All Right" (#7 AC)
1994: "(She's) Some Kind of Wonderful" (#44, #7 AC, #84 U.K.)
"But It's Alright" (#54, #5 AC)
1995: "Little Bitty Pretty One" (#27 AC)
1996: "100 Years From Now" (#10 AC)
2001: "Let Her Go and Start Over" (#23 AC)
"I'm Not In Love Yet" (with Wynonna Judd) --#30 AC